KMID : 0988920090070020100
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Intestinal Research 2009 Volume.7 No. 2 p.100 ~ p.104
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Postinfectious Irritable Bowel Syndrome after Clostridium difficile Infection
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Park Hye-Sun
Jeon Yong-Chul Sohn Joo-Hyun Han Dong-Soo Eun Chang-Soo Bae Joong-Ho Kim Tae-Yeob Ahn Sang-Bong Cho Hyun-Seok Hyun Yil-Sik
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Abstract
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Background/Aims: Post-infectious irritable bowel syndrome (PI-IBS) frequently follows bacterial enterocolitis, and there are various reported incidences and clinical courses according to different pathogens. However, there have rarely been any reports regarding the PI-IBS caused by Clostridium difficile infection (CDI). The aims of this study were to evaluate the incidence and the risk factors for developing IBS following CDI.
Methods: We recruited 86 patients with CDI from January 2005 to October 2007 and also we recruited a comparative control group of 86 patients who had no previous history of any gastroenterological disease. The bowel symptoms were prospectively evaluated by phone through a set questionnaire.
Results: Of all the CDI patients, a total of 41 patients (47.6%) completed the questionnaires, and IBS developed in 8 patients (19.5%), of which 7 patients (87.5%) were the diarrhea type. A total of 51 patients (59.3%) from the control group completed the questionnaires, of which 4 patients (7.8%) developed IBS. Although there was no statistically significant difference (p=0.099), there was a tendency towards a higher incidence of developing IBS in the CDI patients group, as compared to that of the control group. Comparing the group that developed IBS with the group that didn¡¯t among the CDI patients, there were no significantly different factors except for a previous admission history before CDI.
Conclusions: The incidence of PI-IBS after CDI was 19.5%, and the IBS was predominantly the diarrhea-type. In the future, a large scale study needs to be conducted in order to evaluate the PI-IBS incidence after CDI and the risk factors that predispose patients to such conditions.
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KEYWORD
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Irritable Bowel Syndrome, Clostridium difficile Infection
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